Studies Of Caloric Restriction, Resveratrol And Sirt1 Demonstrate A ?Metabotype’ Continuum From Cellular Rejuvenation To Aging To Cancer

are provided abundantly by juvenile cells, but are produced in progressively lessening quantities by aging organs, tissues and cells. However, by turning on a SIRT1 rejuvenation gene cascade, it appears that life extension occurs in the absence of such supplementation. This fact alone has incredible implications, because it proves that the vast majority of youthful cell vigor information, remains intact, and is recoverable with the right inducement(s). The implications are gargantuan, because it declares with a delightful certainty, that normal aging is not, so much so, a process of irreversible decay, as it is a form of highly controlled preplanned obsolescence. The investigation of modified supplementation, in tandem with rejuvenation gene cascade initiation and mitochondrial biogenesis control systems, could offer a fertile field for the cultivation of a broad area of applications. It is becoming progressively more clear that glycolytic and mitochondrial catabolic control systems, in and of themselves, have deep impacts upon cellular function, outside the governance of cell growth control signaling pathways. The notion that such a system has, at its roots, control over such sweeping concepts, as aging, biogenesis, rejuvenation and cancer, is almost stupefying. After all, these systems, and their core control elements, predate multicellularity and the need for differential cell 

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